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Coach trips from La Serena to Santiago

from £9.49

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What to expect of your trip

Fast, easy, and affordable options from La Serena to Santiago

Avg. trip duration

6hr13mins

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Avg. distance

298 miles

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Cheapest trip

From £9.49

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12

Avg. trips a day

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On this page

Bus stations and stops in La Serena

Please note: your ticket will contain the most up-to-date address information.
Best service on board
Available options you can find for a more comfortable trip:
wifi
Free WiFi
Stay connected throughout your journey
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Power Outlets
Keep your devices charged on the go
seat
Comfortable seats
Relax with extra legroom and reclining seats
luggage
Luggage storage
Space to safely stow your belongings
toilet
Toilets
Conveniently available on every FlixBus
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Frequently asked questions

Yes, all FlixBus coaches on the La Serena to Santiago route feature onboard restrooms.
Bus tickets from La Serena to Santiago with FlixBus are available from as low as £9.49.
The route between La Serena and Santiago generally takes about 5 hours 40 minutes by coach and covers approximately 296 miles.
Passengers travelling from La Serena to Santiago by coach are permitted to bring one piece of checked luggage (50x80x30 cm, up to 20 kg) and one hand luggage (30x42x18 cm, up to 7 kg) at no cost. For additional or special luggage, refer to this page. You can bring your bike with FlixBus, subject to availability. Check here for bike prices.
The first coach service from La Serena to Santiago is at 00:50.
The day's last coach departure from La Serena to Santiago is set for 23:59.
There's no requirement for a printed bus ticket for your journey between La Serena and Santiago. After completing your online booking, you'll receive an email containing a PDF with a QR code, which serves as your digital ticket. If you booked via the FlixBus App, your ticket will be saved there. Just present this digital QR code to the driver upon boarding.
In La Serena, there is a singular coach stop: La Serena (Bus terminal La Serena). As for Santiago, it has 6 stops.. You can locate the FlixBus stops on the map above on this page.
Yes, weekend bus options are available from La Serena to Santiago. You can depart on Friday and return on Sunday. Check the bus route’s schedule and choose the best trip to suit your plans!
Yes, night coach services run from La Serena to Santiago. Check the timetable and pick the option that works for you!
Every FlixBus coach between La Serena and Santiago is designed to cater to passengers with mobility constraints. We accommodate wheelchairs, folding chairs, and other mobility aids at no extra charge, and all trips welcome service animals to ensure accessible, comfortable travel.
Yes, most of our coaches on the La Serena -Santiago route are equipped with free WiFi.

Bus travel from La Serena to Santiago: everything you need to know

  • Bus ticket price: you can travel between La Serena and Santiago starting from £9.49 (average ticket cost: £13.99).
  • Average duration: the bus journey from La Serena to Santiago lasts approximately 5 hours 40 minutes.
  • Distance covered: the distance between La Serena and Santiago is 296 miles, with some variation depending on the bus route and intermediate stops.
  • Bus schedules La Serena-Santiago: to check departure times of coaches between La Serena and Santiago, select your travel date: you’ll then see all available trip options with their schedules and prices. You can do this using the selector at the top of this page or by using our interactive map.
  • Bus departure frequency: about 13 departures per day.
  • Bus departure and drop off points: in La Serena, there is a singular coach stop: La Serena (Bus terminal La Serena). As for Santiago, it has 6 stops.. You can locate the FlixBus stops on the map above on this page.
  • Night buses: night bus services are available to depart La Serena in the evening and arrive at Santiago in total comfort.
  • Weekend trips: with FlixBus, you can depart La Serena on Friday and return on Sunday for a perfect weekend getaway in Santiago.
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Onboard services are subject to availability