Skip to main content

Coach trips from Santiago to La Serena

from £9.99

Connecting you to the world

Endless possibilities. Discover over 8,000 destinations across more than 40 countries.

Comfort on the go

Kick back with free Wi-Fi, power outlets, and extra leg space. That's what modern coaches are all about.

Choose, book, travel

From your screen to your seat in seconds. You do the booking, we'll take care of the rest.

Planet-smart travel

Drop the car, travel with us. Increase your mileage and reduce your carbon footprint.

What to expect of your trip

Fast, easy, and affordable options from Santiago to La Serena

Avg. trip duration

6hr14mins

Card icon

Avg. distance

297 miles

Card icon

Cheapest trip

From £9.99

Card icon

12

Avg. trips a day

Card icon

On this page

Bus stations and stops in Santiago

Please note: your ticket will contain the most up-to-date address information.
Best service on board
Available options you can find for a more comfortable trip:
wifi
Free WiFi
Stay connected throughout your journey
socket
Power Outlets
Keep your devices charged on the go
seat
Comfortable seats
Relax with extra legroom and reclining seats
luggage
Luggage storage
Space to safely stow your belongings
toilet
Toilets
Conveniently available on every FlixBus
First time travelling with us?
More on our service
Amenities Hero Image
Where to next?
Discover our travel map with over 8000 destinations worldwide.
Explore the map
Vehicle passing through a city

Frequently asked questions

Yes, all FlixBus coaches on the Santiago to La Serena route feature onboard restrooms.
Bus tickets from Santiago to La Serena with FlixBus are available from as low as £9.99.
The route between Santiago and La Serena generally takes about 6 hours by coach and covers approximately 294 miles.
Passengers travelling from Santiago to La Serena by coach are permitted to bring one piece of checked luggage (50x80x30 cm, up to 20 kg) and one hand luggage (30x42x18 cm, up to 7 kg) at no cost. For additional or special luggage, refer to this page. You can bring your bike with FlixBus, subject to availability. Check here for bike prices.
The first coach service from Santiago to La Serena is at 06:15.
The day's last coach departure from Santiago to La Serena is set for 23:59.
There's no requirement for a printed bus ticket for your journey between Santiago and La Serena. After completing your online booking, you'll receive an email containing a PDF with a QR code, which serves as your digital ticket. If you booked via the FlixBus App, your ticket will be saved there. Just present this digital QR code to the driver upon boarding.
In Santiago, there are 6 coach stops. As for La Serena, it's served by a single stop: La Serena (Bus terminal La Serena). You can locate the FlixBus stops on the map above on this page.
Yes, weekend bus options are available from Santiago to La Serena. You can depart on Friday and return on Sunday. Check the bus route’s schedule and choose the best trip to suit your plans!
Yes, night coach services run from Santiago to La Serena. Check the timetable and pick the option that works for you!
Every FlixBus coach between Santiago and La Serena is designed to cater to passengers with mobility constraints. We accommodate wheelchairs, folding chairs, and other mobility aids at no extra charge, and all trips welcome service animals to ensure accessible, comfortable travel.
Yes, most of our coaches on the Santiago -La Serena route are equipped with free WiFi.

Bus travel from Santiago to La Serena: everything you need to know

  • Bus ticket price: you can travel between Santiago and La Serena starting from £9.99 (average ticket cost: £13.99).
  • Average duration: the bus journey from Santiago to La Serena lasts approximately 6 hours.
  • Distance covered: the distance between Santiago and La Serena is 294 miles, with some variation depending on the bus route and intermediate stops.
  • Bus schedules Santiago-La Serena: to check departure times of coaches between Santiago and La Serena, select your travel date: you’ll then see all available trip options with their schedules and prices. You can do this using the selector at the top of this page or by using our interactive map.
  • Bus departure frequency: about 13 departures per day.
  • Bus departure and drop off points: in Santiago, there are 6 coach stops. As for La Serena, it's served by a single stop: La Serena (Bus terminal La Serena). You can locate the FlixBus stops on the map above on this page.
  • Night buses: night bus services are available to depart Santiago in the evening and arrive at La Serena in total comfort.
  • Weekend trips: with FlixBus, you can depart Santiago on Friday and return on Sunday for a perfect weekend getaway in La Serena.
Person using FlixBus app

Get ready!

Bus arriving in 3 mins.

Scan to download the App
Get the app and travel with ease of mind

Get live updates with push notifications and track your trip in real time. All of your travel details in one place.

android store img app store img

Onboard services are subject to availability